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The Senior Advertising & Promotion Regulatory Content Coordinator (APRCC) is responsible for editorial review of promotional and non-promotional material reviewed by the copy approval team (CAT) to ensure medical, legal, and regulatory guidance is accurately and consistently incorporated prior to distribution. In addition, s/he will proofread materials for consistency with Spark Policy, style guides, and applicable laws and regulations. The RPCE is also responsible for annotating advice....

- Philadelphia, PA
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The Neuroscience Lead (or CNS) will manage the CNS functional group within the Discovery Research group under Translational Research. He/she will be responsible for: - Providing leadership within a group of scientists/research associates, to develop pre-clinical programs from early discovery to the clinic . - Initiate and oversee joint programs with academic collaborators. - Establishing project timelines and ensuring work is completed according to schedule. - Training and developing staff at....


The Corporate Compliance Operations Lead role is responsible for the development, management, execution and delivery of key Corporate Compliance programs including, but not limited to:Learning Management System (“LMS”) for training employees on Corporate policies and Standard Operating ProceduresPolicy, training, and communicationsAggregate Spend related to interactions with Healthcare Professionals (“HCPs”) and Healthcare Organizations (“HCOs”)Ad Board and Consultancy AssessmentsFair Market....


This role is a critical member of the Process Development Leadership team. The PD Downstream & Assay Leader will direct, lead and manage the development of industry scale downstream purification processes for Spark’s purification platforms. This includes, but is not limited to, all the serotypes of recombinant adeno-associated viral vectors (rAAV) from bench research to full scale cGMP manufacture. She/he is responsible for the successful transfer of the developed downstream process to....

- Philadelphia, PA

The Manufacturing Operations Lead has overall responsibility for the Spark Manufacturing Facility at 3737 Market St. This individual will ensure organizational effectiveness by providing leadership and guidance for the team. They will hire and train key manufacturing personnel for both upstream (cell culture) and downstream (purification) activities. Initiate continuous improvement and operational excellence projects to help drive efficiency, while error proofing the process. Ensure the....

- Philadelphia, PA

The Quality Control Analyst will be responsible for conducting development, validation, routine testing and GMP review of analytical assays in compliance with all applicable quality systems and current cGMPs within the Quality Control department at Spark Therapeutics’ facility in Philadelphia, PA. He/She will support the departmental goals and contribute to general operations and analytical testing within the QC laboratory. The primary goals of Quality Control are: to lead the execution of....

- Philadelphia, PA

Support the lab manager in the day-to-day technical operation of the translational lab, inclusive of: assay development, discovery and translational research.Work cross-functionally across all the translational departments to help coordinating the logistic and technical aspects of the different studiesResponsible for sample/reagents shipment storage and orders.Regular assay performance across the different pipeline programs (e.g. ELISA, NAb assay, etc).Help with the management of the inventory

- Philadelphia, PA

The Technical Operations CMC Project Management Lead is responsible for leading cross-functional teams within Technical Operations on multiple projects from inception through completion, coordinating activities to develop the physical product, manufacturing process, supply chain and regulatory files for successful launch and ongoing commercial supply. In this role, the incumbent will build, grow, and mature the CMC function within Technical Operations. This individual must possess strong....

- Philadelphia, PA

The Corporate Engineering Lead will provide engineering leadership, management, and technical support for Spark’s growing facilities and operations. He/she will collaborate with all functions and departments to identify technical and physical infrastructure needs, define end user requirements, and develop and execute solutions appropriate to meet business objectives. He/she will coordinate Federal, State, and City building standards & codes, landlord rules and requirements, and Spark....

- London, United Kingdom

The Medical Affairs Lead – EU Hematology will report to the Medical Strategy Lead – Hematology with an indirect reporting line to the Medical Affairs Lead - EU. They are responsible for leading development and execution of EU-focused medical strategy and tactics, including disease state awareness activities, clinical data presentations, KOL engagement, market access support, and patient identification in support of Spark’s hemophilia program. They will lead hematology-related medical support....


The Senior Patient Advocacy Community Outreach Specialist is responsible for supporting Spark’s interactions with non-profit advocacy organizations serving the hemophilia community, under the direction of the Patient Advocacy Lead (Hematology). This individual will build our presence with regional advocacy partners in the hemophilia community with a focus on raising awareness of, and aiding in educational efforts about, investigational gene therapy research for hemophilia. This is a cross....


Under general guidance from the Analytical Development Lead, working closely with colleagues in R&D and Quality Control, the successful candidate will develop, optimize and qualify analytical methods for use in gene therapy product characterization. Specifically, the candidate will develop chromatographic and electrophoresis methods to provide critical knowledge about AAV-based vectors. S/he will provide written and oral updates to project teams, provide support for regulatory document....

- Philadelphia, PA

Member of the Human Resources team responsible for the execution of proactive recruitment strategies in order to attract key talent in line with corporate objectives. Will develop strong partnerships with internal and external customers, and build pipelines of qualified candidates to meet both existing and forecasted talent needs. Demonstrates and maintains a comprehensive understanding of the marketplace, while continuously building strong recruiting networks and developing innovative and....

- Philadelphia, PA

Reporting to the IT Service Desk Lead, the Lead Desktop Engineer’s primary duties include building advanced solutions for the Desktop Operating System, leading and developing a software deployment solution for computers and mobile devices and account administration automation solutions. This position requires a deep understanding of desktop automation, mobile device systems management, bulk account administration and Microsoft collaboration tools. The lead also will assist in developing....


The Ocular Pre-Clinical Research Lead will manage the Ocular functional group within the Research department. He/she will be responsible for: - Providing leadership within a group of 2 to 3 scientists/research associates, to develop pre-clinical programs from early discovery to the clinic. - Initiate and oversee joint programs with academic collaborators. - Establishing project timelines and ensuring work is completed according to schedule. - Training and developing staff at varying levels of....


The EU Medical Information Leader is responsible for:Leading the creation, review, and approval of timely, accurate, and balanced medical/scientific and technical information (e.g., Medical Information response documents, clinical/value dossiers) across all therapeutic areas for EU Medical Affairs employee and Medical Information Call Center use when responding to unsolicited medical questionsManaging the EU Medical Information Call CenterDocumenting and responding to medical inquiries as....

- Philadelphia, PA

As part of the Technical Operations, Analytical Sciences organization at Spark Therapeutics’ facility in Philadelphia, PA, this role will be responsible for optimizing, validating, and transferring separations and related methods that support Spark products. In addition, this person will develop and conduct qualifying activity related to Critical Reagents and Reference Standards. The primary goals of Analytical Sciences group are to lead the phase-appropriate optimization, and qualification of


Senior Project Manager, Regulatory serves as a resource to the department. The Senior Project Manager, Regulatory will represent the Regulatory function in project teams and manage and track global regulatory projects to established timelines and budgets from initiation through to completion. S/he is responsible for ensuring team and project commitments (ie scope, schedule, budget) are met and for communicating program status to senior leadership on a regular basis. The position will also....

- Philadelphia, PA

The Supply Chain Lead is relied upon to maintain a holistic understanding of the demand and supply dynamics affecting Spark’s US product portfolio. This strategic role combines aspects of product strategy, procurement, supply chain planning and logistics for clinical and commercial supply of novel gene therapies. The Supply Chain Lead is responsible for supporting launch and post launch product strategy delivery for the US Market. S/he will drive and execute supply chain and operations....

- Philadelphia, PA

The Process Development Scientist is a key role in the Process Development Analytical team. He/she will function as an Analytical Scientist to develop and implement new assays, optimize existing assays based on in-depth knowledge of laboratory techniques and perform analytical experiments to support upstream and downstream process development at Spark. The major responsibilities are as follows, but not limited to:Conduct analytical experiments to support process development of Upstream,....

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