Current Openings

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- Philadelphia, PA

The Manufacturing Operations Lead has overall responsibility for the Spark Manufacturing Facility at 3737 Market St. This individual will ensure organizational effectiveness by providing leadership and guidance for the team. They will hire and train key manufacturing personnel for both upstream (cell culture) and downstream (purification) activities. Initiate continuous improvement and operational excellence projects to help drive efficiency, while error proofing the process. Ensure the....

- Philadelphia, PA

The Quality Control Analyst will be responsible for conducting development, validation, routine testing and GMP review of analytical assays in compliance with all applicable quality systems and current cGMPs within the Quality Control department at Spark Therapeutics’ facility in Philadelphia, PA. He/She will support the departmental goals and contribute to general operations and analytical testing within the QC laboratory. The primary goals of Quality Control are: to lead the execution of....

- Philadelphia, PA

The Technical Operations CMC Project Management Lead is responsible for leading cross-functional teams within Technical Operations on multiple projects from inception through completion, coordinating activities to develop the physical product, manufacturing process, supply chain and regulatory files for successful launch and ongoing commercial supply. In this role, the incumbent will build, grow, and mature the CMC function within Technical Operations. This individual must possess strong....

- Philadelphia, PA

As part of the Technical Operations, Analytical Sciences organization at Spark Therapeutics’ facility in Philadelphia, PA, this role will be responsible for optimizing, validating, and transferring separations and related methods that support Spark products. In addition, this person will develop and conduct qualifying activity related to Critical Reagents and Reference Standards. The primary goals of Analytical Sciences group are to lead the phase-appropriate optimization, and qualification of

- Philadelphia, PA

The Supply Chain Lead is relied upon to maintain a holistic understanding of the demand and supply dynamics affecting Spark’s US product portfolio. This strategic role combines aspects of product strategy, procurement, supply chain planning and logistics for clinical and commercial supply of novel gene therapies. The Supply Chain Lead is responsible for supporting launch and post launch product strategy delivery for the US Market. S/he will drive and execute supply chain and operations....


The senior quality control microbiology technician will perform cGMP testing to support manufacturing activities by primarily performing environmental monitoring, gown training & qualifications, and microbial testing. This position will support facility qualification, validation, and routine testing of microbiological assays. The selected candidate will be accountable to communicate and lead Alert/Action investigations, create and revise SOP’s, forms, logbooks, and reports as necessary. He

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