Current Openings

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- Philadelphia, PA
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Under general guidance from the Analytical Development Lead, working closely with colleagues in R&D and Quality Control, the successful candidate will develop, optimize and qualify analytical methods for use in gene therapy product characterization. Specifically, the candidate will develop chromatographic and electrophoresis methods to provide critical knowledge about AAV-based vectors. S/he will provide written and oral updates to project teams, provide support for regulatory document....

- Philadelphia, PA

The Research Scientist is a key member of the Liver Discovery Research Group and participates in the development of Spark’s liver-targeted gene therapy products. She/he will actively participate in the development of novel targets, facilitating translation from in vitro through in vivo proof of concept. He/she will be responsible for:Collaborating with other Translational Research Scientists to develop pre-clinical programs from early discovery to the clinic.Designing and conducting in vitro....


The Senior animal research associate will be responsible for overseeing and performing in vivo studies to support all the therapeutic areas of the translational team. Responsible for the submission, amendment and continuation of IACUC protocols covering all small animal studiesPrimary interface with regulatory agencies for animal welfare and veterinarial staff within the animal facilitySupervise the current in vivo staff membersOversee and perform large numbers of in vivo studiesMaintain....


The Liver Pre-Clinical Research Lead position requires extensive translational experience with gene therapies targeting the liver. The successful candidate would have in-depth familiarity with target validation and lead identification/optimization, using a combination of molecular, cellular and in vitro/in vivo techniques for hepatic gene therapy programs. He or she should be familiar with delivery techniques targeting the liver and have substantial experience with studies in laboratory....


The successful candidate will be a key member of the Translational Research group assisting on projects across different stages of pre-clinical studies. He/she will proactively engage and work alongside scientists to support and execute experiments in order to drive scientific innovation.RESPONSIBILITIES:Monitor and maintain inventory and stock assigned areasMaintain lab medias and buffer stocksMaintain lab supply inventoryMaintain lab equipmentPlasmid PrepsPerform limited troubleshooting and....

- Philadelphia, PA

Support the lab manager in the day-to-day technical operation of the translational lab, inclusive of: assay development, pharmacology & toxicology, and discovery research. Maximize operating effectiveness of translational research programs:Ensure optimal interactions across functionsDevelop and implement processes that maximize productivityDevelop and improve assay protocolsOptimize resource utilizationSupport the evolution of operating models to meet growth objectivesProvide input and....

- Philadelphia, PA

The Ocular Research Scientist is a member of the Ocular functional group within Translational Research. He/she will be responsible for:Design, execution and data analysis for ocular-directed research programs.Write study reports, manuscripts and present results at appropriate scientific meetings.Initiate and oversee joint programs with external collaborators. RESPONSIBILITIES:Hands-on execution of in vitro and in vivo experiments on the bench.Identify and validate new indication targets and....


Support the Ocular Research team with laboratory-based functions:Assist ocular research team in developing early discovery and pre-clinical programsPerform routine assays including data analysis and results interpretationAssist ocular research team with in vitro and in vivo studiesIdentify opportunities to improve routine assaysChampion all safety aspects in the Translational Laboratories RESPONSIBILITIES: 60% Help planning and perform experiments in support of the Ocular research....

- Philadelphia, PA

Provides event planning and communications support to R&D. The primary accountability is to ensure the needs of the function are prioritized, organized and executed to maximize internal and external communication. This is accomplished by coordinating the input from various leaders, broader R&D and corporate support as required to ensure events are consistent with R&D communication plans.Daily activities include but are not limited to R&D external event planning with a focus on....

- Philadelphia, PA

The Head of Clinical Development is responsible for defining the vision and clinical strategies that will support Spark’s product development and commercialization objectives, and for the design and successful execution of clinical trials. S/he will take a leadership role in analysis and interpretation of clinical results for regulatory submissions and publications, and will provide medical/clinical support in strategic planning activities and will assist in evaluation of new business....

- Philadelphia, PA

The Neuroscience Lead (or CNS) will manage the CNS functional group within the Discovery Research group under Translational Research. He/she will be responsible for: - Providing leadership within a group of scientists/research associates, to develop pre-clinical programs from early discovery to the clinic . - Initiate and oversee joint programs with academic collaborators. - Establishing project timelines and ensuring work is completed according to schedule. - Training and developing staff at....


The Ocular Pre-Clinical Research Lead will manage the Ocular functional group within the Research department. He/she will be responsible for: - Providing leadership within a group of 2 to 3 scientists/research associates, to develop pre-clinical programs from early discovery to the clinic. - Initiate and oversee joint programs with academic collaborators. - Establishing project timelines and ensuring work is completed according to schedule. - Training and developing staff at varying levels of....

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