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The Downstream Development Lead will be responsible for design, development, and tech transfer of unit operations supporting the purification of Spark’s gene therapy assets. This role is responsible for all phases of downstream development from bench-scale through cGMP-scale processes. This individual will be a key player in downstream technical transfers to both internal cGMP manufacturing and CDMOs, as well as troubleshooting of cGMP manufacturing technical issues related to the purification


This position is a key participant in the day-to-day operation and planning of rAAV vector production related work, with primary responsibility to execute established protocols of manufacturing research and pre-clinical grade rAAV vectors. The individual in the role will participate in (but not be limited to) manufacturing of rAAV vectors including cell culture, vector production and purification, and rAAV related assays. Additionally, the individual will contribute to the implementation of....

- Philadelphia, PA

The Analytical Development Lead will manage all aspects of gene therapy based product analytical methods development to support Spark’s pipeline of cutting edge recombinant viral vector-based products. They will build on Spark’s pioneering vector analytical strengths through optimization of existing methods, and by development, optimization and validation of new cutting edge methods. They will work in a highly interdiciplinary environment and be expected to communicate effectively and....

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