Current Openings

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- Philadelphia, PA
new job!

The IT Infrastructure Operations Lead is responsible for managing all IT infrastructure technologies for servers, storage, infrastructure and data centers. This role is responsible for deployment, management and oversight of all production and non-production IT systems. Responsible for data-center services including data-center facilities both local and cloud, monitoring and management of systems, disaster recovery services, IT Service Management functions, and the processes and resources....

- Philadelphia, PA
new job!

The Downstream Development Lead will be responsible for design, development, and tech transfer of unit operations supporting the purification of Spark’s gene therapy assets. This role is responsible for all phases of downstream development from bench-scale through cGMP-scale processes. This individual will be a key player in downstream technical transfers to both internal cGMP manufacturing and CDMOs, as well as troubleshooting of cGMP manufacturing technical issues related to the purification

- Philadelphia, PA
new job!

This position is a key participant in the day-to-day operation and planning of rAAV vector production related work, with primary responsibility to execute established protocols of manufacturing research and pre-clinical grade rAAV vectors. The individual in the role will participate in (but not be limited to) manufacturing of rAAV vectors including cell culture, vector production and purification, and rAAV related assays. Additionally, the individual will contribute to the implementation of....

- Philadelphia, PA

The Drug Product Manufacturing Lead will oversee and manage the external drug product manufacturing vendors and sites (CMOs) providing final formulation, aseptic filling and packaging/labeling services for drug product intended for commercial and/or clinical distribution. The incumbent will lead cross-functional programs to ensure a consistent approach across drug product manufacturing sites through formalized technology transfer procedures, standardized comparability and process validation....


As a member of the Clinical Operations Team, the Clinical Project Manager/Senior Clinical Project Manager designs, plans, implements and executes the overall direction of clinical projects from protocol development, selection and qualification of vendors/investigational sites, operationalization of study activities (startup through closeout) and finalization of clinical study reports. S/he will collaborate with cross functional teams to design and develop clinical study protocols, develop and....


The Medical Science Liaison (MSL) will be responsible for providing non-promotional scientific, educational, and research support for Spark Therapeutic gene therapy portfolio in the respective territory. The MSL position is a field based member of the Medical Affairs team. The MSL should be highly trained in a health care field and well versed in clinical practice and basic science. The MSL should be able to deliver cutting edge data and technical/practical education to Health Care....


The Head of IT Infrastructure Operations is responsible for the smooth operation of all Spark IT Infrastructure and Help Desk service delivery. This includes data centers, networks, help desk, telecommunications, cyber security, web services, specialized departmental applications and related technologies and services. This position requires a mix of strategic IT planning and tactical execution skills. This position requires a proven track record in data center and network operations, IT....

- Philadelphia, PA

This role is a critical member of the Global Medical Affairs team. The ideal candidate will be responsible for development and implementation of high-impact strategic publications, physician-directed communications, medical education, and medical advocacy plans for company products. The ideal candidate will have significant leadership experience in the pharmaceutical industry, experience with scientific publications, and the ability to develop collaborative relationships with colleagues, key....

- Philadelphia, PA

The Senior Clinical Contracts Coordinator is responsible for providing support to the clinical operations group by coordinating the approval process for various clinical trial documents across all studies. S/he will assist the clinical project managers and other members of the team to facilitate timely approval of documents. RESPONSIBILITIES:Work across all studies and therapeutic areas to support clinical study teams.Work with Spark legal to identify acceptable alternative/fallback language....

- Philadelphia, PA

The individual in this position will be responsible for a specific geographic area and will play a key role in educating healthcare professionals on treatment for hemophilia patients. This education will include clinical, psychosocial, as well as financial considerations for patients and their families. An emphasis will be placed on an investigational approach to treat or prevent genetic disease that is showing exciting potential for hemophilia patients. Effective internal and external....

- Philadelphia, PA

Responsible for IT security, data privacy, compliance and IT risk management at Spark. This person is responsible for formulating and operationalizing plans for IT security, global data privacy, business continuity and other security risk areas. This is a hands-on role, but this individual must possess strong technical expertise with IT security technologies along with a strategic vision to develop and implement a global security and privacy framework. RESPONSIBILITIES:Research, design and....

- Philadelphia, PA

The Regulatory Affairs Associate, under general guidance, prepares, reviews and submits high quality, regulatory submissions to the FDA, EMA and other health authorities within company timelines and in accordance with regulatory guidelines and applicable federal laws. Submissions include amendments, supplements, annual reports, DSURs and additional documents as needed. Compiles and reviews amendments, supplements, annual reports, etc., for FDA and other health authority submissions. Interacts....


This role is a critical member of the Global Medical Affairs team. The ideal candidate will will spend 50% of their time on hemophilia and 25% of their time on ophthalmology. He/She will be responsible for development and implementation of high-impact strategic publications, physician-directed communications, medical education, and medical advocacy plans for company products. The ideal candidate will have significant experience in the pharmaceutical industry, experience with scientific....

- Philadelphia, PA

This position within the Translational department consists of two major roles. First, the successful candidate will be required to interact with contract research organizations (CROs) and external collaborators in order to coordinate the planning, design, and execution of the in-life portion of a variety of in vivo studies. Second, the successful candidate will support the research teams performaning assays on the bench. The main responsibilities of this position include but are not limited to

- Philadelphia, PA

The Patient Services Leader is responsible for the operational and tactical leadership of the Spark Therapeutics US Patient Services field (Patient Access Liaisons or PAL) and home office-based (Patient Access Specialists or PAS) teams. The Leader will be responsible for operationalizing strategy by aligning Spark values, patient services objectives, measurements, incentives and execution with the goal of assisting patients access to therapy. Working across the organization, this highly....

- Philadelphia, PA

The primary responsibilities of the Patient Services Lead are ownership and operational leadership of the case management process and systems including managing the internal Patient Access Specialists (PAS) team for Spark’s gene therapy products. The incumbent is responsible for providing day-to-day instructions to team members on job responsibilities. This includes hiring, training, managing, and developing the patient specialists. Working with the Patient Services Leader, the incumbent is....


The Sr Business Analyst, Enterprise Applications is responsible for planning, design, configuration, deployment and support of the Enterprise Resource Planning system in support of Manufacturing, Materials Management and Finance operations and processes. The Sr. Analyst must be able to provide both application support in a business analyst capacity as well as technical support and project management. This includes gathering and analyzing data in support of business cases and proposed projects....


The Sr Business Analyst, Enterprise Applications is responsible for planning, design, configuration, deployment and support of HR, Finance and Commercial business systems in support of operations and processes within the Corporate functions. The Sr. Analyst must be able to provide both application support in a business analyst capacity as well as technical support and project management. This includes gathering and analyzing data in support of business cases and proposed projects as well as....


Provides high caliber administrative support to the President and Head of R&D in a fast-paced and highly dynamic setting. The primary accountability is to ensure the needs of the executive and their function are prioritized, organized and executed in order to maximize their productivity. Daily responsibilities include calendar management, scheduling of meetings, phone support, expense reports, travel arrangements, external conference registration, word processing of documents (including....


The Sr. Quality Control Microbiologist will support method transfer, method qualification, method suitability testing, validation and routine testing of microbiological assays. This role will coordinate the development and implementation of new programs that govern general and microbiology specific laboratory practices, lead OOS and Alert / Action Investigations, generate deviation documentation and trend reports, and assist with audit preparation and participation. He or she will create,....

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