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- Philadelphia, PA
new job!

As part of the Technical Operations, Analytical Sciences organization at Spark Therapeutics’ facility in Philadelphia, PA, this role will be responsible for optimizing, validating, and transferring separations and related methods that support Spark products. In addition, this person will develop and conduct qualifying activity related to Critical Reagents and Reference Standards. The primary goals of Analytical Sciences group are to lead the phase-appropriate optimization, and qualification of

- London, United Kingdom
new job!

The EU Medical Information Leader is responsible for:Leading the creation, review, and approval of timely, accurate, and balanced medical/scientific and technical information (e.g., Medical Information response documents, clinical/value dossiers) across all therapeutic areas for EU Medical Affairs employee and Medical Information Call Center use when responding to unsolicited medical questionsManaging the EU Medical Information Call CenterDocumenting and responding to medical inquiries as....

- Philadelphia, PA
new job!

The Corporate Engineering Lead will provide engineering leadership, management, and technical support for Spark’s growing facilities and operations. He/she will collaborate with all functions and departments to identify technical and physical infrastructure needs, define end user requirements, and develop and execute solutions appropriate to meet business objectives. He/she will coordinate Federal, State, and City building standards & codes, landlord rules and requirements, and Spark....

- Philadelphia, PA
new job!

Reporting to the IT Service Desk Lead, the Lead Desktop Engineer’s primary duties include building advanced solutions for the Desktop Operating System, leading and developing a software deployment solution for computers and mobile devices and account administration automation solutions. This position requires a deep understanding of desktop automation, mobile device systems management, bulk account administration and Microsoft collaboration tools. The lead also will assist in developing....

- Philadelphia, PA
new job!

Senior Project Manager, Regulatory serves as a resource to the department. The Senior Project Manager, Regulatory will represent the Regulatory function in project teams and manage and track global regulatory projects to established timelines and budgets from initiation through to completion. S/he is responsible for ensuring team and project commitments (ie scope, schedule, budget) are met and for communicating program status to senior leadership on a regular basis. The position will also....

- Philadelphia, PA

The Supply Chain Lead is relied upon to maintain a holistic understanding of the demand and supply dynamics affecting Spark’s US product portfolio. This strategic role combines aspects of product strategy, procurement, supply chain planning and logistics for clinical and commercial supply of novel gene therapies. The Supply Chain Lead is responsible for supporting launch and post launch product strategy delivery for the US Market. S/he will drive and execute supply chain and operations....

- Philadelphia, PA

The Process Development Scientist is a key role in the Process Development Analytical team. He/she will function as an Analytical Scientist to develop and implement new assays, optimize existing assays based on in-depth knowledge of laboratory techniques and perform analytical experiments to support upstream and downstream process development at Spark. The major responsibilities are as follows, but not limited to:Conduct analytical experiments to support process development of Upstream,....


The Process Development Scientist-Purification is key team member in the development of Spark’s fully scalable purification processes of recombinant adeno-associated viral vectors (rAAV). She/he will actively participate in the process validation (PV) project. The major responsibilities are, but not limited, to following: Work with other PD scientist team members to develop fully scalable purification process of rAAV vectors.Design and conduct experiments to optimize purification conditions to


Provides ongoing administrative support to multiple members of a department in a fast-paced environment. The primary accountability is to ensure the needs of the function are prioritized, organized and executed in order to maximize productivity. This is accomplished by coordinating the support of the various leaders, as well as routine departmental support as requested. Daily items for assigned personnel include calendar management, scheduling of meetings and interviews, phone support, expense

- Philadelphia, PA

Support the lab manager in the day-to-day technical operation of the translational lab, inclusive of: assay development, discovery and translational research.Work cross-functionally across all the translational departments to help coordinating the logistic and technical aspects of the different studiesResponsible for sample/reagents shipment storage and orders.Regular assay performance across the different pipeline programs (e.g. ELISA, NAb assay, etc).Help with the management of the inventory


Provides ongoing administrative support to multiple members of a department in a fast-paced environment. The primary accountability is to ensure the needs of the function are prioritized, organized and executed in order to maximize productivity. This is accomplished by coordinating the support of the various leaders, as well as routine departmental support as requested. Daily items for assigned personnel include calendar management, scheduling of meetings and interviews, phone support, expense


The Ocular Pre-Clinical Research Lead will manage the Ocular functional group within the Research department. He/she will be responsible for: - Providing leadership within a group of 2 to 3 scientists/research associates, to develop pre-clinical programs from early discovery to the clinic. - Initiate and oversee joint programs with academic collaborators. - Establishing project timelines and ensuring work is completed according to schedule. - Training and developing staff at varying levels of....


The IT Infrastructure & Operations Lead is responsible for the smooth operation of all Spark IT Infrastructure and Help Desk service delivery. This includes data centers, networks, help desk, telecommunications, cyber security, web services, specialized departmental applications and related technologies and services. This position requires a mix of strategic IT planning and tactical execution skills. This position requires a proven track record in data center and network operations, IT....

- Philadelphia, PA

The Neuroscience Lead (or CNS) will manage the CNS functional group within the Discovery Research group under Translational Research. He/she will be responsible for: - Providing leadership within a group of scientists/research associates, to develop pre-clinical programs from early discovery to the clinic . - Initiate and oversee joint programs with academic collaborators. - Establishing project timelines and ensuring work is completed according to schedule. - Training and developing staff at....

- Philadelphia, PA

The Corporate Communications Lead will report to the Head of Corporate Communications and be based in Philadelphia, PA. The person will be, at different times, a writer, project manager, event manager, digital expert, critical/creative thinker, storyteller, and communication expert as part of a small communications team with a driving ambition to break down barriers for patients and families affected by debilitating genetic diseases globally. The Corporate Communications Lead will be....


The Senior Patient Advocacy Community Outreach Specialist is responsible for supporting Spark’s interactions with non-profit advocacy organizations serving the hemophilia community, under the direction of the Patient Advocacy Lead (Hematology). This individual will build our presence with regional advocacy partners in the hemophilia community with a focus on raising awareness of, and aiding in educational efforts about, investigational gene therapy research for hemophilia. This is a cross....

- Philadelphia, PA

The Quality Control Analyst will be responsible for conducting development, validation, routine testing and GMP review of analytical assays in compliance with all applicable quality systems and current cGMPs within the Quality Control department at Spark Therapeutics’ facility in Philadelphia, PA. He/She will support the departmental goals and contribute to general operations and analytical testing within the QC laboratory. The primary goals of Quality Control are: to lead the execution of....


The senior quality control microbiology technician will perform cGMP testing to support manufacturing activities by primarily performing environmental monitoring, gown training & qualifications, and microbial testing. This position will support facility qualification, validation, and routine testing of microbiological assays. The selected candidate will be accountable to communicate and lead Alert/Action investigations, create and revise SOP’s, forms, logbooks, and reports as necessary. He

- Philadelphia, PA

The Senior Infrastructure Engineer is responsible for the end-to-end requirements elicitation, design, testing, and successful transition of Spark’s internal and vendor-enabled infrastructure, messaging, storage, network, security & continuity services. Additional responsibilities include planning, organization, and management of related programs, projects and ITIL processes to ensure service level consistency and optimization. The Senior Infrastructure Engineer will also define forward....

- Philadelphia, PA

The technical operations CMC Project Management Lead is responsible for leading cross-functional teams on multiple projects from inception through completion, while adhering to project scope, schedule, quality and budget. The project manager must possess strong communication skills and must be savvy working with both technology, process development, analytical development, manufacturing and business partners across the organization in a collaborative way. In this role, the incumbent prepares....

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