Current Openings

Research Scientist – Liver Group

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Philadelphia, PA
Job Type
Direct Hire
Jan 26, 2017
Job ID
The Research Scientist is a member of the Liver Discovery Research functional group within the Discovery Research group under Translational Research. He/she will be responsible for:
  • Design and construction of optimized gene expression cassettes to increase transgene expression derived from liver cells.
  • Design, execution and data analysis for liver-directed discovery research programs.
  • Write study reports, manuscripts and present results at appropriate scientific meetings.
  • Initiate and oversee joint programs with external collaborators.
80% of the time
  • Identify and validate new indication targets and optimize gene expression cassettes to support both existing and new programs in the pipeline. This includes executing experiments on the bench, extensive literature review, championing product candidate development from proof of concept to IND submission, etc.
20% of the time
  • Prepare sample analysis reports and write parts of regulatory submissions to regulatory agencies.
  • Hands-on experience in hepatic gene therapy techniques, such as intravenous injection, hepatocyte isolation, etc.
  • Strong organizational skills.
  • Excellent writing and verbal communication skills.
  • Ph.D. in relevant scientific discipline required (e.g. cell and molecular biology, biochemistry, etc.)
  • Minimum 0-2 years of hands-on research experience with gene therapies targeting the liver
  • In-depth familiarity with target lead identification/optimization using a combination of molecular, cellular and in vitro/in vivo techniques for hepatic gene therapy programs.
  • Familiarity with delivery techniques targeting the liver
  • Experience with studies in laboratory animals
  • Experience with AAV vectors is required
  • Strong publication record is a plus.
Transforming Patient’s Lives.
 Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.