Current Openings

Liver Discovery Research Lead

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Location
Philadelphia, PA
Job Type
Direct Hire
Date
Apr 18, 2017
Job ID
2382666
The Liver Discovery Research Lead will manage the Liver functional group within the Discovery Research group under Translational Research. He/she will be responsible for:

•    Providing leadership within in a group of scientists/research associates, to develop pre-clinical programs from early discovery to the clinic.
•    Initiate and oversee joint programs with academic collaborators. 
•    Establishing project timelines and ensuring work is completed according to schedule.
•    Training and developing staff at varying levels of experience.

The Liver Discovery Research Lead position requires extensive translational experience with gene therapies targeting the liver, including:

•    In-depth familiarity with target validation and lead identification/optimization, using a combination of molecular, cellular and in vitro/in vivo techniques for hepatic gene therapy programs. 
•    Familiar with delivery techniques targeting the liver and have substantial experience with studies in laboratory animals. 
•    Some familiarity with AAV, as well as some knowledge of clinical trial design and regulatory strategy, is preferred. 

RESPONSIBILITIES: 
  • Hands-on execution of experiments on the bench
  • Identify and validate new indication targets. Design and trouble-shoot experiments based on personal experience and literature review. Prepare and deliver scientific presentations at internal and external meetings
  • Prioritize projects, plan workload, manage resource and personnel scheduling
  • Preparing sample analysis reports and write parts of regulatory submissions to FDA
  • Lead a team of scientists.  Mentor and develop staff.
  • Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.
EDUCATION and EXPERIENCE REQUIREMENTS: 
  • Ph.D. in relevant scientific discipline (e.g. cell and molecular biology, biochemistry, etc.) 
  • Minimum 5-8 years of hands-on experience in the field of gene therapy. 
  • Previous management or supervisory experience strongly preferred.
KEY SKILLS, ABILITIES and COMPETENCIES: 
  • Extensive hands-on experience in hepatic gene therapy techniques, such as intravenous injection, hepatocyte isolation, etc. 
  • Strong organizational skills.
  • Excellent writing and verbal communication skills.
  • Previous management experience preferred, but not required.
  • Strong publication record is a plus.
  • Experience with AAV vectors is a plus.
COMPLEXITY and PROBLEM SOLVING: 
  • Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems. Discuss with supervisor and refer to policies/practices for guidance.
  • Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
  • Exercise judgment within defined procedures and practices to determine appropriate action.
INTERNAL and EXTERNAL CONTACTS: 
  • Quality Assurance, Clinical Operations, Pharm/Tox, Discovery, Assay Development, R&D Operations, Technical Operations, Regulatory Affairs, Executive Team.

WHO WE ARE:
Transforming Patient’s Lives. 
Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.





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