Current Openings

Liver Discovery Research Lead

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Philadelphia, PA
Job Type
Direct Hire
Apr 18, 2017
Job ID
The Liver Discovery Research Lead will manage the Liver functional group within the Discovery Research group under Translational Research. He/she will be responsible for:

•    Providing leadership within in a group of scientists/research associates, to develop pre-clinical programs from early discovery to the clinic.
•    Initiate and oversee joint programs with academic collaborators. 
•    Establishing project timelines and ensuring work is completed according to schedule.
•    Training and developing staff at varying levels of experience.

The Liver Discovery Research Lead position requires extensive translational experience with gene therapies targeting the liver, including:

•    In-depth familiarity with target validation and lead identification/optimization, using a combination of molecular, cellular and in vitro/in vivo techniques for hepatic gene therapy programs. 
•    Familiar with delivery techniques targeting the liver and have substantial experience with studies in laboratory animals. 
•    Some familiarity with AAV, as well as some knowledge of clinical trial design and regulatory strategy, is preferred. 

  • Hands-on execution of experiments on the bench
  • Identify and validate new indication targets. Design and trouble-shoot experiments based on personal experience and literature review. Prepare and deliver scientific presentations at internal and external meetings
  • Prioritize projects, plan workload, manage resource and personnel scheduling
  • Preparing sample analysis reports and write parts of regulatory submissions to FDA
  • Lead a team of scientists.  Mentor and develop staff.
  • Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.
  • Ph.D. in relevant scientific discipline (e.g. cell and molecular biology, biochemistry, etc.) 
  • Minimum 5-8 years of hands-on experience in the field of gene therapy. 
  • Previous management or supervisory experience strongly preferred.
  • Extensive hands-on experience in hepatic gene therapy techniques, such as intravenous injection, hepatocyte isolation, etc. 
  • Strong organizational skills.
  • Excellent writing and verbal communication skills.
  • Previous management experience preferred, but not required.
  • Strong publication record is a plus.
  • Experience with AAV vectors is a plus.
  • Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems. Discuss with supervisor and refer to policies/practices for guidance.
  • Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
  • Exercise judgment within defined procedures and practices to determine appropriate action.
  • Quality Assurance, Clinical Operations, Pharm/Tox, Discovery, Assay Development, R&D Operations, Technical Operations, Regulatory Affairs, Executive Team.

Transforming Patient’s Lives. 
Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.